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  • Niacin: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)

This product received a low safety score because the 750mg dose of niacin is over 21 times higher than the recommended maximum daily limit of 35mg.

Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

750 mg (3750% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 21.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 750mg UL 35mg

Other Ingredients

Lactose Hypromellose Stearic Acid Titanium Dioxide Magnesium Stearate Magnesium Silicate Triacetin mineral oil Sodium Lauryl Sulfate

Label Claims — Verification

All Other
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS: Adults only: One tablet daily, as a dietary supplement, or as directed by a physician.

⚠️ Warnings & Precautions

CAUTION: Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing dose, or changing brand of niacin. These effects seldom require discontinuing niacin use. Skin rash, upset stomach, and low blood pressure when standing are less common symptoms; if they persist, contact a physician.

WARNINGS: Do not use this product if you have a known sensitivity or allergy to niacin.

Use only under the advice and supervision of a physician if you: -have heart disease, recurrent chest pain (angina), or recently suffered a heart attack, -are taking high blood pressure or cholesterol-lowering drugs (because of possible drug interactions), -have any of the following conditions: gallbladder disease, gout, arterial bleeding, glaucoma, diabetes, impaired liver function, peptic ulcer, or are a pregnant or lactating woman.

TAMPER RESISTANT - DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING

KEEP OUT OF REACH OF CHILDREN.

Increased uric acid and glucose levels and abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of niacin. Discontinue use and consult a physician immediately if any of the following symptoms occur: persistent flu-like symptoms (nausea, vomiting, a general "not well" feeling), loss of appetite, a decrease in urine output associated with dark colored urine, muscle discomfort such as tender, swollen muscles or weakness, irregular heartbeat; or cloudy or blurry vision.

🧪 Formulation Notes

Contains milk.

Free of starch, gluten, sodium, yeast, soy, corn, preservatives, nuts and artificial colors-flavors.

Additional Information

Rugby - SATISFACTION GUARANTEED - OR YOUR MONEY BACK

Questions or comments? Call 1-800-645-2158, weekdays 9 am-5 pm ET

Control No.: Exp. Date:

To preserve quality and freshness, keep bottle tightly closed. Store between 15(0) - 30(0)C (59(0) - 85(0)F)

225 R0908

Product Details

UPC / SKU 0 0536-7033-01 2
DSLD Entry Date 2012-08-24
Product Type Vitamin
Form Tablet or Pill
Brand Rugby
DSLD ID 12232
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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