Glucosamine Relief 500 mg by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

120 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Glucosamine Sulfate

500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 500mg

Other Ingredients

Gelatin Magnesium Silicate Silicon Dioxide Stearic Acid Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take up to three (3) capsules daily after any meal, or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

WARNING: IF YOU ARE DIABETIC, CONSULT YOUR PHYSICIAN BEFORE USING THIS PRODUCT.

If you have a Shellfish allergy please consult your medical practitioner before using this product.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

🧪 Formulation Notes

No Added Sugar, Salt, Yeast, Preservatives, or Artificial Flavors.

This product contains glucosamine sulfate derived from shrimp and crab shells.

Additional Information

Store at room temperature.

Unconditionally guaranteed for purity, freshness and label potency.

MADE IN USA

0206

Helps Maintain the Natural Lubrication Found in Joints and Cartilage*

BEST VALUE

Glucosamine sulfate, found in the soft cartilage, tendons, and synovial fluid, is essential to the healthy functioning of tendons and joints, especially with advancing age.*

Product Details

UPC / SKU 7 40985 27012 7

DSLD Entry Date 2012-07-25

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand 21st Century

DSLD ID 11294

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →