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E-400

product on market Softgel Capsule 21st Century Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin E acts as an antioxidant that helps protect cells from oxidative stress. There is strong evidence supporting its role in maintaining immune function and skin health. This ingredient profile is generally considered safe for most adults.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for E-400
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 IU (1333% DV)
17.9× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)

Other Ingredients

Gelatin Glycerin refined Soybean Oil purified Water
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one (1) or two (2) softgels daily for maximum daily results, or as directed by your healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Keep out of reach of children.

Do not use if product appears to be tampered with.

Formulation Notes

Contains a soy ingredient.

No Added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.

Additional Information

Vitamin E-400

21st Century's vitamin E-400 interacts with many vitamins and minerals. It helps in the maintenance of red blood cells and is an essential antioxidant nutrient. Recent research has been published about the importance of Vitamin E in your daily diet.*

0207

VALUE SIZE

MADE IN USA

Naturally Supports A Healthy Heart And Boosts The Immune System*

Unconditionally guaranteed for purity, freshness and label potency.

Store at room temperature.

Metadata

Product Details

UPC / SKU7 40985 21025 3
DSLD Entry Date2012-07-25
Product TypeVitamin
FormSoftgel Capsule
Brand21st Century
DSLD ID11213
Data Updated2026-04-11
Research

Research Evidence

253
Research Sources
55
Avg Quality
128
Meta Analysis
52
Systematic Review
41
Rct
24
Clinical Trial
3
Regulatory Source
1
Narrative Review
1
Other
1
Guideline
1
Openfda Safety
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin E for Alzheimer's disease and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2008 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2012 PubMed DOI
A Exercise for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2021 PubMed DOI
A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Meta Analysis European journal of clinical nutrition 2023 PubMed DOI
A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Rct JAMA 2011 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2022 PubMed DOI
View all evidence for Vitamin E →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.