E-400 by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Softgel(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin E

400 IU (1333% DV)

📊 17.9× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 268.0mg UL 1000mg

Other Ingredients

Gelatin Glycerin refined Soybean Oil purified Water

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (98% of products) Structure/Function (81% of products) Nutrient (56% of products) Qualified Health (2% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: Take one (1) or two (2) softgels daily for maximum daily results, or as directed by your healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Keep out of reach of children.

Do not use if product appears to be tampered with.

🧪 Formulation Notes

Contains a soy ingredient.

No Added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.

Additional Information

Vitamin E-400

21st Century's vitamin E-400 interacts with many vitamins and minerals. It helps in the maintenance of red blood cells and is an essential antioxidant nutrient. Recent research has been published about the importance of Vitamin E in your daily diet.*

0207

VALUE SIZE

MADE IN USA

Naturally Supports A Healthy Heart And Boosts The Immune System*

Unconditionally guaranteed for purity, freshness and label potency.

Store at room temperature.

Product Details

UPC / SKU 7 40985 21025 3

DSLD Entry Date 2012-07-25

Product Type Vitamin

Form Softgel Capsule

Brand 21st Century

DSLD ID 11213

Data Updated 2026-04-11

Research Evidence

253 Research Sources

55 Avg Quality Score

128 Meta Analysis

52 Systematic Review

41 Rct

24 Clinical Trial

3 Regulatory Source

1 Narrative Review

1 Other

1 Guideline

1 Openfda Safety

A Vitamin E supplementation in pregnancy

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Systematic Review The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin E for Alzheimer's disease and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

A Exercise for intermittent claudication

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2021

PubMed DOI

A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis

Meta Analysis European journal of clinical nutrition 2023

PubMed DOI

A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Rct JAMA 2011

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.

Guideline JAMA 2022

PubMed DOI

View all evidence for Vitamin E →