Vitamin E × Antiplatelet Drugs
MODERATE
Probable Evidence
Mechanism
High-dose vitamin E may inhibit platelet aggregation, additive with antiplatelet drugs.
Effect
Increased bleeding risk at doses >400 IU/day
Management
Avoid vitamin E >400 IU/day with antiplatelet drugs. Monitor for bleeding.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyTaking high doses of Vitamin E with antiplatelet drugs can increase your risk of bleeding. This happens because large amounts of Vitamin E can work together with the medication to further prevent blood cells from clumping together to form clots.
Source
Corrigan JJ Jr. Am J Clin Nutr 1991
Research
Supporting Research
Exercise for intermittent claudication
Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Antioxidants for chronic kidney disease
Exercise for intermittent claudication
Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease
Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.