Vitamin D × Digoxin
MODERATE
Probable Evidence
Mechanism
Vitamin D promotes calcium absorption. Hypercalcemia potentiates digoxin toxicity.
Effect
Increased risk of digoxin toxicity if hypercalcemia develops
Management
Monitor serum calcium and digoxin levels. Avoid excessive vitamin D dosing.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination carries a moderate risk. Vitamin D helps your body absorb more calcium, and if calcium levels become too high, it can increase the risk of digoxin toxicity.
Source
FDA digoxin labeling; Cheung K et al. J Clin Pharm Ther 2013
Research
Supporting Research
Interventions for preventing falls in older people in care facilities and hospitals
High prevalence of vitamin D deficiency in Asia: A systematic review and meta-analysis
The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
Interventions for preventing falls in older people living in the community
Interventions for preventing falls in older people in nursing care facilities and hospitals
Interventions for preventing falls in older people living in the community
Interventions for preventing falls in older people in care facilities and hospitals
Interventions for preventing falls in older people in care facilities
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.