Vitamin C × Warfarin
MINOR
Possible Evidence
Mechanism
High-dose vitamin C may affect warfarin clearance, though evidence is weak.
Effect
Possible minor INR changes at very high doses (>5g/day)
Management
Monitor INR if taking high-dose vitamin C. Normal dietary intake is safe.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is generally safe at normal dietary levels, but very high doses of vitamin C may slightly affect how warfarin works. Taking more than 5 grams of vitamin C per day could potentially cause minor changes in your blood clotting levels.
Source
Harris JE. JAMA 1971 (case report only)
Research
Supporting Research
Vitamin E supplementation in pregnancy
Nutritional interventions for preventing and treating pressure ulcers
Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis
Reminder packaging for improving adherence to self-administered long-term medications
Nutritional interventions for preventing and treating pressure ulcers
Interventions to reduce haemorrhage during myomectomy for fibroids
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.