Vitamin C × Aluminum Interaction

Mechanism

Vitamin C increases aluminum absorption from antacids and phosphate binders.

Effect

Increased aluminum levels; potential toxicity in renal impairment

Management

Separate vitamin C from aluminum-containing products by at least 2 hours.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination can be moderately problematic because Vitamin C increases the amount of aluminum your body absorbs from certain medications. Higher aluminum levels can potentially lead to toxicity, especially for individuals with kidney disease.

Source

Fulton B, Jaworski AJ. Ann Pharmacother 1995

Research

Supporting Research

Vitamin E supplementation in pregnancy

PMID:26343254 DOI 2015

Nutritional interventions for preventing and treating pressure ulcers

PMID:38345088 DOI 2024

Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis

PMID:39201285 DOI 2024

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

PMID:34325683 DOI 2021

Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis

PMID:34684565 DOI 2021

Reminder packaging for improving adherence to self-administered long-term medications

PMID:21901694 DOI 2011

Nutritional interventions for preventing and treating pressure ulcers

PMID:24919719 DOI 2014

Interventions to reduce haemorrhage during myomectomy for fibroids

PMID:25125317 DOI 2014

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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.