⚠️ Mechanism
Vitamin C increases aluminum absorption from antacids and phosphate binders.
📋 Effect
Increased aluminum levels; potential toxicity in renal impairment
💊 Management
Separate vitamin C from aluminum-containing products by at least 2 hours.
Plain Language Summary
This combination can be moderately problematic because Vitamin C increases the amount of aluminum your body absorbs from certain medications. Higher aluminum levels can potentially lead to toxicity, especially for individuals with kidney disease.
Source
Fulton B, Jaworski AJ. Ann Pharmacother 1995
Supporting Research
Vitamin E supplementation in pregnancy
Nutritional interventions for preventing and treating pressure ulcers
Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis
Reminder packaging for improving adherence to self-administered long-term medications
Nutritional interventions for preventing and treating pressure ulcers
Interventions to reduce haemorrhage during myomectomy for fibroids
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.