⚠️ Mechanism
Vitamin A and synthetic retinoids (isotretinoin, acitretin) both activate retinoid receptors. Combined use causes additive toxicity.
📋 Effect
Hypervitaminosis A: hepatotoxicity, pseudotumor cerebri, teratogenicity
💊 Management
Avoid vitamin A supplements with systemic retinoids. Do not exceed RDA.
Plain Language Summary
This combination is dangerous. Taking vitamin A supplements while using retinoid medications can cause too much vitamin A to build up in your body, which can lead to serious health problems like liver damage or increased pressure in the brain.
Source
FDA isotretinoin labeling; Vahlquist A et al. Dermatology 2008
Supporting Research
Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Food fortification with multiple micronutrients: impact on health outcomes in general population
Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Integrated management of childhood illness (IMCI) strategy for children under five
Health outcomes associated with micronutrient-fortified complementary foods in infants and young children aged 6-23 months: a systematic review and meta-analysis
Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.