Home/ Interactions/ Valerian × Warfarin
Do not combine without physician supervision. If you are already taking both Valerian and Warfarin, contact your healthcare provider today. Do not stop any medication without professional guidance.

Valerian × Warfarin

CRITICAL Cyp-Inferred Evidence

Mechanism

Valerian is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of warfarin (warfarin), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of warfarin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination is dangerous because Valerian can prevent your body from breaking down warfarin properly. This may cause the level of medication in your blood to rise, increasing your risk of serious side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Non-pharmacological interventions for sleep promotion in the intensive care unit
PMID:26439374 DOI 2015
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review
PMID:33495257 DOI 2021
Herbal medicine for insomnia: A systematic review and meta-analysis
PMID:25644982 DOI 2015
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review
PMID:39064758 DOI 2024
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
PMID:33561990 DOI 2021
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review
PMID:28137522 DOI 2017
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons
PMID:26403118 DOI 2015
A systematic review of insomnia and complementary medicine
PMID:20965131 DOI 2011
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.