⚠️ Mechanism
Valerian is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of theophylline (theophylline), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of theophylline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous because Valerian can slow down how your body breaks down theophylline. This may cause the medication to build up in your system, increasing the risk of serious side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Non-pharmacological interventions for sleep promotion in the intensive care unit
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review
Herbal medicine for insomnia: A systematic review and meta-analysis
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons
A systematic review of insomnia and complementary medicine
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.