Valerian × Ssri
MINOR
Possible Evidence
Mechanism
Valerian has weak serotonergic activity; theoretical risk of serotonin syndrome with SSRIs.
Effect
Possible additive serotonergic effect (rare)
Management
Generally safe at typical doses. Report any agitation or confusion.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is generally considered safe at typical doses. However, because both can influence serotonin levels, there is a very small risk of causing an excess of this chemical, which could lead to symptoms like confusion or agitation.
Source
Doughty MJ. J Pharm Pharm Sci 2018
Research
Supporting Research
Non-pharmacological interventions for sleep promotion in the intensive care unit
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review
Herbal medicine for insomnia: A systematic review and meta-analysis
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons
A systematic review of insomnia and complementary medicine
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.