⚠️ Mechanism
Valerian has weak serotonergic activity; theoretical risk of serotonin syndrome with SSRIs.
📋 Effect
Possible additive serotonergic effect (rare)
💊 Management
Generally safe at typical doses. Report any agitation or confusion.
Plain Language Summary
This combination is generally considered safe at typical doses. However, because both can influence serotonin levels, there is a very small risk of causing an excess of this chemical, which could lead to symptoms like confusion or agitation.
Source
Doughty MJ. J Pharm Pharm Sci 2018
Supporting Research
Non-pharmacological interventions for sleep promotion in the intensive care unit
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review
Herbal medicine for insomnia: A systematic review and meta-analysis
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons
A systematic review of insomnia and complementary medicine
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.