⚠️ Mechanism
Tyrosine is a catecholamine precursor. MAOIs prevent catecholamine breakdown. Combined use causes dangerous hypertension.
📋 Effect
Hypertensive crisis (dangerously high blood pressure)
💊 Management
Absolutely avoid combination. Can cause stroke or death.
Plain Language Summary
This combination is dangerous. Taking Tyrosine with MAOIs can cause a sudden, life-threatening spike in blood pressure that can lead to a stroke or death.
Source
FDA MAOI labeling; Cooper AJ. Biol Psychiatry 1989
Supporting Research
Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating
Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial.
Functional and metabolic effects of omega-3 polyunsaturated fatty acid supplementation and the role of β-hydroxy-β-methylbutyrate addition in chronic obstructive pulmonary disease: A randomized clinical trial.
Behavioral and cognitive effects of tyrosine intake in healthy human adults
Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults
The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress
Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC.
Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions.
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.