Do not combine without physician supervision. If you are already taking both St Johns Wort and Abiraterone, contact your healthcare provider today. Do not stop any medication without professional guidance.
St Johns Wort × Abiraterone
CRITICAL
Ddinter-Verified Evidence
Mechanism
Interaction identified from DDInter 2.0 database. Specific drugs: Abiraterone
Effect
See mechanism description
Management
Consult healthcare provider before combining.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is considered dangerous because it can cause a serious interaction. St. John's Wort may change how your body processes Abiraterone, which could make the medication less effective.
Source
DDInter 2.0 (ddinter.scbdd.com)
Research
Supporting Research
The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Hypericum extract LI 160 and fluoxetine in mild to moderate depression: a randomized, placebo-controlled multi-center study in outpatients
PMID:15538592
2005
[Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects]
PMID:12212522
2002
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression
PMID:12008860
2002
Efficacy of continuation treatment with hypericum perforatum in depression
PMID:12019675
2002
Predicting stable treatment response in patients with major depression treated with hypericum extract WS 5570/5572
PMID:16189745
2005
Adverse Event Profile: St Johns Wort
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.