⚠️ Mechanism
Red yeast rice contains monacolin K (lovastatin). Combined with prescription statins, this doubles statin dose and increases myopathy/rhabdomyolysis risk.
📋 Effect
Additive statin effect; increased myopathy and rhabdomyolysis risk
💊 Management
Avoid combination. Red yeast rice IS a statin — do not combine with prescription statins.
Plain Language Summary
This combination is dangerous because red yeast rice contains the same active ingredient found in prescription statins. Taking them together can act like a double dose, which increases the risk of serious muscle damage.
Source
FDA warning; Gordon RY et al. Am J Cardiol 2010
Supporting Research
Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials
Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Original Research: The Effects of Red Yeast Rice Supplementation on Cholesterol Levels in Adults
Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial
Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials
Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis
Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.