Omega 3 × Warfarin
MODERATE
Possible Evidence
Mechanism
High-dose omega-3 may reduce platelet aggregation, potentially additive with warfarin.
Effect
Possible increased bleeding risk at high doses (>3g/day)
Management
Monitor INR. Low-dose omega-3 (<1g/day) generally safe.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyTaking high doses of omega-3 with warfarin may increase your risk of bleeding. This occurs because large amounts of omega-3 can further thin your blood, adding to the effect of your medication.
Source
Buckley MS et al. Ann Pharmacother 2004
Research
Supporting Research
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
Non-immunosuppressive treatment for IgA nephropathy
Interventions for fatigue and weight loss in adults with advanced progressive illness
Motor control exercise for chronic non-specific low-back pain
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Reduced or modified dietary fat for preventing cardiovascular disease
WITHDRAWN: Interventions for fatigue and weight loss in adults with advanced progressive illness
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.