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Licorice × Immunosuppressants

CRITICAL INTERACTION

⚠️ Mechanism

Licorice is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

📋 Effect

Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.

💊 Management

Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

This combination is dangerous. Licorice can prevent your body from breaking down certain immunosuppressant drugs, which may cause the medication to build up to unsafe levels in your blood. This increase can lead to serious side effects or toxicity.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Supporting Research

Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial PMID:36451559 2022
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.