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Licorice × ARB

MODERATE Cyp-Inferred Evidence

Mechanism

Licorice is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of losartan (arb), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of losartan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination can be moderately risky because licorice may prevent your body from breaking down your blood pressure medication properly. This can cause the medication to build up in your system, which may increase your risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
PMID:36451559 2022
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.