⚠️ Mechanism
Licorice causes potassium loss via pseudohyperaldosteronism, while ACE inhibitors can raise potassium. Complex interaction.
📋 Effect
Hypokalemia from licorice may counteract ACE inhibitor potassium-sparing effect
💊 Management
Avoid licorice supplements. Monitor potassium levels.
Plain Language Summary
This combination can be problematic because it affects your potassium levels in opposing ways. While ACE inhibitors help your body retain potassium, licorice can cause your body to lose it, which may interfere with the medication's effect.
Source
Olukoga A, Donaldson D. J R Soc Med 2000
Supporting Research
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.