Home/ Interactions/ Licorice × Ace Inhibitors

Licorice × Ace Inhibitors

MODERATE Well-Established Evidence

Mechanism

Licorice causes potassium loss via pseudohyperaldosteronism, while ACE inhibitors can raise potassium. Complex interaction.

Effect

Hypokalemia from licorice may counteract ACE inhibitor potassium-sparing effect

Management

Avoid licorice supplements. Monitor potassium levels.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination can be problematic because it affects your potassium levels in opposing ways. While ACE inhibitors help your body retain potassium, licorice can cause your body to lose it, which may interfere with the medication's effect.

Source

Olukoga A, Donaldson D. J R Soc Med 2000

Research

Supporting Research

Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
PMID:36451559 2022
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.