⚠️ Mechanism
Kava potentiates GABA-A receptor activity, additive with benzodiazepines and other CNS depressants.
📋 Effect
Severe CNS depression; excessive sedation; coma risk
💊 Management
Avoid combination. Kava + benzodiazepines has caused semi-comatose states.
Plain Language Summary
This combination is dangerous. Kava can significantly increase the effects of sedatives, which may lead to extreme sleepiness or even a coma.
Source
Almeida JC et al. Ann Intern Med 2002; Chen X et al. J Ethnopharmacol 2015
Supporting Research
Kava in generalized anxiety disorder: three placebo-controlled trials
Explanatory attributions of anxiety and recovery in a study of kava
Kava-Kava administration reduces anxiety in perimenopausal women
Kava treatment in patients with anxiety
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.