Kava × Opioids Interaction

Do not combine without physician supervision. If you are already taking both Kava and Opioids, contact your healthcare provider today. Do not stop any medication without professional guidance.

Mechanism

Kava is a strong inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of codeine (opioids), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of codeine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination is dangerous. Kava can prevent your body from breaking down opioids like codeine, which may cause the medication to build up to unsafe levels in your system. This increase can lead to a higher risk of serious side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Kava in generalized anxiety disorder: three placebo-controlled trials

PMID:16877894 2006

Explanatory attributions of anxiety and recovery in a study of kava

PMID:15253862 2004

Kava-Kava administration reduces anxiety in perimenopausal women

PMID:12590005 2003

Kava treatment in patients with anxiety

PMID:15162364 2004

Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines

PMID:11605083 2001

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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.