⚠️ Mechanism
Kava is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous because Kava can prevent your body from breaking down certain immunosuppressants, causing them to build up in your system. This increase in drug levels can lead to a higher risk of serious side effects or toxicity.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Kava in generalized anxiety disorder: three placebo-controlled trials
Explanatory attributions of anxiety and recovery in a study of kava
Kava-Kava administration reduces anxiety in perimenopausal women
Kava treatment in patients with anxiety
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.