⚠️ Mechanism
Iodine supplementation directly counteracts antithyroid drugs (methimazole, PTU) which work by blocking iodine utilization.
📋 Effect
Reduced antithyroid drug efficacy; worsening hyperthyroidism
💊 Management
Avoid iodine supplements with antithyroid drugs. Monitor thyroid function.
Plain Language Summary
This combination can be problematic because iodine supplements interfere with how antithyroid drugs work. The supplement can counteract the medication's ability to block thyroid activity, which may lead to worsening hyperthyroidism.
Source
Leung AM, Braverman LE. Thyroid 2012
Supporting Research
Umbilical cord antiseptics for preventing sepsis and death among newborns
Interventions for cutaneous molluscum contagiosum
Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis
Radioiodine Remnant Ablation for Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis
Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia
Interventions for ingrowing toenails
Interventions for the management of malignant pleural effusions: a network meta-analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.