⚠️ Mechanism
Green tea catechins may inhibit intestinal CYP3A4, potentially increasing simvastatin absorption.
📋 Effect
Possible increased simvastatin levels
💊 Management
Minor clinical concern. Monitor for statin side effects with heavy green tea consumption.
Plain Language Summary
This combination is generally considered safe, though it presents a minor risk. Drinking large amounts of green tea may cause more of the medication to be absorbed into your system, which could increase the chance of experiencing side effects.
Source
Chow HH et al. Clin Pharmacol Ther 2006
Supporting Research
The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis
Green Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies
Green tea (Camellia sinensis) for the prevention of cancer
The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
Green tea consumption and risk of pancreatic cancer: a meta-analysis
Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review
Dietary Strategies for Weight Loss Maintenance
Green and black tea for the primary prevention of cardiovascular disease
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.