Green Tea × Simvastatin Interaction

Mechanism

Green tea catechins may inhibit intestinal CYP3A4, potentially increasing simvastatin absorption.

Effect

Possible increased simvastatin levels

Management

Minor clinical concern. Monitor for statin side effects with heavy green tea consumption.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination is generally considered safe, though it presents a minor risk. Drinking large amounts of green tea may cause more of the medication to be absorbed into your system, which could increase the chance of experiencing side effects.

Source

Chow HH et al. Clin Pharmacol Ther 2006

Research

Supporting Research

The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis

PMID:36036958 DOI 2024

Green Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies

PMID:30513889 DOI 2018

Green tea (Camellia sinensis) for the prevention of cancer

PMID:32118296 DOI 2020

The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis

PMID:39683599 DOI 2024

Green tea consumption and risk of pancreatic cancer: a meta-analysis

PMID:25353660 DOI 2014

Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review

PMID:37878272 DOI 2023

Dietary Strategies for Weight Loss Maintenance

PMID:31443231 DOI 2019

Green and black tea for the primary prevention of cardiovascular disease

PMID:23780706 DOI 2013

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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.