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Green Tea × Antidiabetic Drugs

MODERATE Cyp-Inferred Evidence

Mechanism

Green Tea is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of repaglinide (antidiabetic-drugs), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of repaglinide. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination carries a moderate risk because green tea can slow down how your body processes certain diabetes medications. This may cause the medication to build up in your bloodstream, which could increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis
PMID:36036958 DOI 2024
Green Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies
PMID:30513889 DOI 2018
Green tea (Camellia sinensis) for the prevention of cancer
PMID:32118296 DOI 2020
The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
PMID:39683599 DOI 2024
Green tea consumption and risk of pancreatic cancer: a meta-analysis
PMID:25353660 DOI 2014
Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review
PMID:37878272 DOI 2023
Dietary Strategies for Weight Loss Maintenance
PMID:31443231 DOI 2019
Green and black tea for the primary prevention of cardiovascular disease
PMID:23780706 DOI 2013
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.