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Green Tea × Antiarrhythmics

CRITICAL INTERACTION

⚠️ Mechanism

Green Tea is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

📋 Effect

Increased plasma levels of amiodarone (antiarrhythmics), potentially leading to toxicity or enhanced adverse effects.

💊 Management

Monitor for increased adverse effects of amiodarone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

This combination is considered dangerous because green tea can prevent your body from breaking down certain heart medications properly. This may cause the medication to build up to unsafe levels in your bloodstream, increasing the risk of serious side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Supporting Research

The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis PMID:36036958 DOI:10.1080/10408398.2022.2113360 2024
Green Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies PMID:30513889 DOI:10.3390/nu10121886 2018
Green tea (Camellia sinensis) for the prevention of cancer PMID:32118296 DOI:10.1002/14651858.CD005004.pub3 2020
The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis PMID:39683599 DOI:10.3390/nu16234206 2024
Green tea consumption and risk of pancreatic cancer: a meta-analysis PMID:25353660 DOI:10.3390/nu6114640 2014
Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review PMID:37878272 DOI:10.1001/jamadermatol.2023.3949 2023
Dietary Strategies for Weight Loss Maintenance PMID:31443231 DOI:10.3390/nu11081916 2019
Green and black tea for the primary prevention of cardiovascular disease PMID:23780706 DOI:10.1002/14651858.CD009934.pub2 2013
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.