⚠️ Mechanism
Ginkgo is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous. Ginkgo can prevent your body from breaking down GI prokinetics properly, which may cause the medication to build up to unsafe levels in your blood. This increase in medication levels can lead to a higher risk of serious side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)