⚠️ Mechanism
Garlic may induce CYP2E1, increasing metabolism of chlorzoxazone.
📋 Effect
Reduced muscle relaxant effect
💊 Management
Monitor for reduced efficacy. Minor clinical concern.
Plain Language Summary
This interaction is considered minor and is not typically dangerous. However, garlic may cause your body to break down chlorzoxazone more quickly, which could make the muscle relaxant less effective.
Source
Gurley BJ et al. Drug Metab Dispos 2002
Supporting Research
Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials
Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
Garlic for the common cold
Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in meats: A meta-analysis
A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia
Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials
Garlic for the common cold
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.