⚠️ Mechanism
Echinacea is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination is dangerous because Echinacea can slow down how your body breaks down GI prokinetics. This may cause the medication to build up to unsafe levels in your blood, increasing the risk of serious side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis
Herbal Medicine in Children With Respiratory Tract Infection: Systematic Review and Meta-Analysis
Herbal Medicine for Cough: a Systematic Review and Meta-Analysis
Rabbit dietary supplementation with pale purple coneflower. 1. Effects on the reproductive performance and immune parameters of does
Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis
Interaction of herbal products with prescribed medications: A systematic review and meta-analysis
Echinacea for treating the common cold: a randomized trial
Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.