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Echinacea × Analgesics

MODERATE Cyp-Inferred Evidence

Mechanism

Echinacea is a moderate inhibitor of CYP1A2, which decreases metabolism of CYP1A2 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of acetaminophen (analgesics), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of acetaminophen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination may be unsafe because it can cause acetaminophen levels to rise unexpectedly in your body. Echinacea can slow down how your body breaks down this pain reliever, which may increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis
PMID:38999738 DOI 2024
Herbal Medicine in Children With Respiratory Tract Infection: Systematic Review and Meta-Analysis
PMID:28610802 DOI 2018
Herbal Medicine for Cough: a Systematic Review and Meta-Analysis
PMID:26840418 DOI 2015
Rabbit dietary supplementation with pale purple coneflower. 1. Effects on the reproductive performance and immune parameters of does
PMID:26763800 DOI 2016
Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis
PMID:33809656 DOI 2021
Interaction of herbal products with prescribed medications: A systematic review and meta-analysis
PMID:30660822 DOI 2019
Echinacea for treating the common cold: a randomized trial
PMID:21173411 DOI 2010
Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children
PMID:30465062 DOI 2019
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.