⚠️ Mechanism
Calcium interferes with bisphosphonate absorption when taken simultaneously.
📋 Effect
Reduced bisphosphonate absorption; decreased bone density benefit
💊 Management
Take bisphosphonate at least 30 minutes before calcium or any food/drink.
Plain Language Summary
This combination is moderately problematic because taking them together can interfere with how your body absorbs the medication. Calcium can prevent the bisphosphonate from being fully absorbed, which may reduce its effectiveness in helping your bones.
Source
FDA alendronate labeling; Gertz BJ et al. Clin Pharmacol Ther 1993
Supporting Research
First-line drugs for hypertension
Beta-blockers for hypertension
Calcium channel blockers versus other classes of drugs for hypertension
Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event
Phlebotonics for venous insufficiency
Calcium channel blockers versus other classes of drugs for hypertension
Calcium supplementation for prevention of primary hypertension
Calcium supplementation for prevention of primary hypertension
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.