Home/ Interactions/ Caffeine × Lithium

Caffeine × Lithium

MODERATE Well-Established Evidence

Mechanism

Caffeine increases renal lithium clearance. Abrupt caffeine cessation can increase lithium levels.

Effect

Variable lithium levels; toxicity risk if caffeine stopped suddenly

Management

Maintain consistent caffeine intake. Do not abruptly stop or start caffeine.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination can be risky because caffeine affects how your body removes lithium. Suddenly stopping your caffeine intake can cause lithium levels to rise, which may lead to toxicity.

Source

Mester R et al. J Clin Psychiatry 1995; Jefferson JW. Biol Psychiatry 1988

Research

Supporting Research

The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
PMID:30335479 DOI 2019
Effects of caffeine chewing gum supplementation on exercise performance: A systematic review and meta-analysis
PMID:35239468 DOI 2023
Genetic susceptibility to caffeine intake and metabolism: a systematic review
PMID:39438936 DOI 2024
Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis
PMID:36615805 DOI 2022
Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes
PMID:29509641 DOI 2018
Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis
PMID:33800853 DOI 2021
Effect of Acute Caffeine Intake on Fat Oxidation Rate during Fed-State Exercise: A Systematic Review and Meta-Analysis
PMID:38257100 DOI 2024
The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis
PMID:29876876 DOI 2018
← Caffeine All Interactions →

Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.