Caffeine × Chemotherapy
MODERATE
Ddinter-Verified Evidence
Mechanism
Interaction identified from DDInter 2.0 database. Specific drugs: Bendamustine, Methotrexate, Bendamustine, Methotrexate, Bendamustine, Methotrexate
Effect
See mechanism description
Management
Consult healthcare provider before combining.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is considered a moderate interaction, meaning it may not be safe for everyone. Caffeine can potentially interfere with how these chemotherapy drugs work in your body.
Source
DDInter 2.0 (ddinter.scbdd.com)
Research
Supporting Research
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Effects of caffeine chewing gum supplementation on exercise performance: A systematic review and meta-analysis
Genetic susceptibility to caffeine intake and metabolism: a systematic review
Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis
Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes
Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis
Effect of Acute Caffeine Intake on Fat Oxidation Rate during Fed-State Exercise: A Systematic Review and Meta-Analysis
The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.