Black Cohosh × Statins
MODERATE
Possible Evidence
Mechanism
Black cohosh may inhibit CYP3A4, potentially increasing statin levels (especially simvastatin/atorvastatin).
Effect
Increased statin levels; possible myopathy risk
Management
Monitor for statin side effects (muscle pain). Consider pravastatin as alternative.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination requires caution because Black Cohosh may cause certain statins to build up in your system. This increase in medication levels can raise the risk of experiencing muscle pain or weakness.
Source
Gurley BJ et al. Clin Pharmacol Ther 2006
Research
Supporting Research
[Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]
PMID:32762163
2020
Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause
Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract
Menopausal symptoms
PMID:19450302
2007
Menopausal symptoms
PMID:21696644
2011
Menopausal symptoms
PMID:21718582
2010
Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis
Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis
PMID:20085176
2010
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.