⚠️ Mechanism
Black cohosh may inhibit CYP3A4, potentially increasing statin levels (especially simvastatin/atorvastatin).
📋 Effect
Increased statin levels; possible myopathy risk
💊 Management
Monitor for statin side effects (muscle pain). Consider pravastatin as alternative.
Plain Language Summary
This combination requires caution because Black Cohosh may cause certain statins to build up in your system. This increase in medication levels can raise the risk of experiencing muscle pain or weakness.
Source
Gurley BJ et al. Clin Pharmacol Ther 2006
Supporting Research
[Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]
Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause
Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract
Menopausal symptoms
Menopausal symptoms
Menopausal symptoms
Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis
Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.