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ALT

Liver Unit: U/L

Liver enzyme indicating hepatocellular damage

Also known as: Alanine Aminotransferase,SGPT,Alanine Transaminase (ALT),Alanine Transaminase

Reference Ranges

Clinical Reference 7.0 – 56.0 U/L

Optimal Range 10.0 – 30.0 U/L

Critical Range > 500.0 U/L

Liver-specific enzyme; elevated in hepatocellular injury

Related Conditions

Liver Disease High

Food & Lifestyle Recommendations

🍎 Food Reduce alcohol, fructose, and processed foods; increase cruciferous vegetables and coffee (3+ cups/day) Coffee intake is inversely associated with ALT and liver disease in large cohort studies

🍎 Food Mediterranean diet pattern is associated with lower ALT and reduced fatty liver risk Meta-analyses show Mediterranean diet reduces NAFLD risk by 30%

Evidence-Backed Supplements

When High

Milk Thistle Tier A May Decrease

Silymarin shows hepatoprotective effects in some RCTs

Silymarin extract (70–80%) 140–210 mg silymarin 2–3x/day With meals

PMID 40552569 PMID 37816677 PMID 40738719
Nac Tier A May Decrease

Supports glutathione production; evidence for acetaminophen recovery

N-Acetyl Cysteine 600–1200 mg/day Morning or divided doses

PMID 30746681 PMID 39349461 PMID 33294991
Milk Thistle Tier A Hepatoprotective

Silymarin has hepatoprotective effects; may reduce ALT in NAFLD

Silymarin extract (70–80%) 140–210 mg silymarin 2–3x/day With meals

PMID 40552569 PMID 37816677 PMID 40738719
Nac Tier A Supports Glutathione

NAC replenishes glutathione; evidence for acetaminophen toxicity and some liver conditions

N-Acetyl Cysteine 600–1200 mg/day Morning or divided doses

PMID 30746681 PMID 39349461 PMID 33294991

Questions to Ask Your Doctor

Should I be screened for fatty liver disease given my elevated ALT? NAFLD is the most common cause of elevated ALT
Could my medications or supplements be causing my elevated liver enzymes? Many drugs and supplements are hepatotoxic

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