🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

2 Caplet(s) Serving Size
30 Servings
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

Calcium
260 mg (26% DV)
Sodium
15 mg (1% DV)
Plant Sterols and Plant Stanols
900 mg

Other Ingredients

Plant Sterols Plant Stanols Calcium Carbonate Tribasic Calcium Phosphate Croscarmellose Sodium Hydroxypropyl Methylcellulose Silicon Dioxide Magnesium Stearate Color added Polyethylene Glycol Triethyl Citrate Polysorbate 80

Label Claims — Verification

Nutrient
All Other
Approved Health
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Take two caplets two times daily with meals. For easier swallowing, take with water before and during ingestion.

When to take with the most substantial meal of the day

⚠️ Warnings & Precautions

Caution: Not for use by children or pregnant or lactating women.

Caution: Not for use by children or pregnant or lactating women. Check with your physician before using CholestOff Original if you are currently using medications to lower your cholesterol.

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

🧪 Formulation Notes

With plant sterols and stanols

Color Derived from natural source - No synthetic dyes No artificial flavors - No preservatives No yeast or starch - Gluten free

Supplies 900 mg of plant sterols and stanols per serving for a daily intake of 1800 mg

CholestOff Original is made with Reducol, a proprietary blend of plant sterols and stanols (also called phytosterols) that can help lower LDL (“bad”) cholesterol by reducing the absorption of dietary cholesterol into the bloodstream.

CholestOff Original provides the additional 1800 milligrams of plant sterols and stanols needed to help meet what the NCEP recommends for cholesterol reduction.

One serving of Nature Made CholestOff Original supplies 900 mg of plant sterols and stanols per serving for a daily intake of 1800 mg.

Additional Information

Lowers dietary cholesterol

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

Helps lower LDL (“bad”) cholesterol

A healthy cholesterol level is an important part of heart health.

The National Institutes of Health (NIH) Therapeutic Lifestyle Change Guidelines recommends 2000 milligrams of plant sterols and stanols as part of a therapeutic diet to help lower cholesterol. However, many Americans only consume 200 milligrams through their diet.

Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.

Available Sizes: 60 count / 120 count

Product Details

DSLD Entry Date 2018-01-25
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand Nature Made
DSLD ID 82539
Data Updated 2026-04-11

Research Evidence

849 Research Sources
56 Avg Quality Score
450 Meta Analysis
152 Rct
137 Systematic Review
73 Clinical Trial
11 Regulatory Source
7 Other
7 Guideline
3 Openfda Safety
2 Cochrane Review
2 Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021
View all evidence for Electrolytes →

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