100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
Limited research evidence available for ingredients

B Label Compliance Grade

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

1 Capsule(s)

Serving Size

Botanical

Product Type

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Senna leaf extract

125 mg

Market median: 142.5mg (70 products)

Other Ingredients

Cellulose Vegetable Cellulose Capsule Stearic Acid

Claims

Label Claims — Verification

Unverified All Other

Unverified Structure/Function

Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one capsule daily.

Warnings & Precautions

Keep out of reach of children.

Warning: This product contains Senna. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Senna may worsen these conditions and be harmful to your health.

Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Formulation Notes

Vegetarian Standardized extract

Warning: This product contains Senna.

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, gluten free, no soy, no dairy, yeast free.

Additional Information

Store in a cool, dry place.

Natural laxative

CODE 195612 ARG

Metadata

Product Details

UPC / SKU0 48107 12890 6

DSLD Entry Date2017-08-22

Product TypeBotanical

FormCapsule

BrandGNC Herbal Plus

DSLD ID74665

Data Updated2026-04-11

Research

Research Evidence

Research Sources

Avg Quality

Rct

Other

Meta Analysis

Narrative Review

C The Efficacy of Senna Bowel Preparation for Colonoscopy: A Systematic Review and Meta-analysis

Meta Analysis Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates PubMed DOI

C Pre-administration of super-low volume polyethylene glycol is as effective as senna laxative as bowel preparation for colonoscopy: a randomized controlled phase 2 trial

Rct Surgical endoscopy 2022 PubMed DOI

C Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study

Rct Journal of gastroenterology and hepatology 2020 PubMed DOI

C Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination

Rct BMJ (Clinical research ed.) 1993 PubMed

C Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial

Rct The American journal of gastroenterology 2021 PubMed DOI

C Polyethylene glycol powder solution versus senna for bowel preparation for colonoscopy in children

Rct Journal of pediatric gastroenterology and nutrition 2013 PubMed DOI

C Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation

Rct Journal of pediatric surgery 2017 PubMed DOI

D Standardized senna in the management of constipation in the puerperium: A clinical trial

Rct South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1980 PubMed

D Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients

Rct Pharmacology 1993 PubMed

D Assessing product adulteration in natural health products for laxative yielding plants, Cassia, Senna, and Chamaecrista, in Southern India using DNA barcoding

Other International journal of legal medicine 2015 PubMed DOI

View all evidence for Senna →

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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.