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Extra Strength Milk Thistle Extract 450 mg/80%

product on market Softgel Capsule Protocol For Life Balance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Milk thistle extract contains silymarin, which has shown moderate evidence in supporting liver health and protecting hepatocytes from toxins. Research suggests it may aid in the management of certain liver conditions, though clinical results vary. The product maintains a high safety profile for general use.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Extra Strength Milk Thistle Extract 450 mg/80%
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)

Other Ingredients

Softgel Capsule organic Sunflower Oil Sunflower Lecithin Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USAGE: Take 1 softgel daily, or as directed by your healthcare practitioner.

Warnings & Precautions

CAUTIONS/INTERACTIONS: Milk Thistle may interact with some drugs, including acetaminophen.

May trigger mild, transient GI discomfort.

Consult your healthcare practitioner if you are pregnant/nursing or if you suffer from obstruction of the bile ducts, gallstones, or gallbladder dysfunction.

Do not take this product if you have an allergy to plants of the Asteraceae family.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

Non-GMO

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients.

This Extra Strength product has more Milk Thistle Extract (450 mg per softgel) than our regular strength product (300 mg per capsule).

Additional Information

HOW IT WORKS: Milk Thistle (Silybum marianum) has been used by traditional herbalists for centuries. Silymarin, an extract of Milk Thistle, is composed of a family of flavonoids, including Silybin, with smaller amounts of Silydianin and Silychristin. Milk Thistle has been shown to support the production of glutathione by the liver.* Studies indicate that the constituents in Silymarin may help to support healthy liver function.*

CODE P4785 V1

Liver Support*

~ Promotes Glutathione Production* ~ Softgels for Improved Solubility

Non-GMO

GMP

Metadata

Product Details

UPC / SKU7 07359 14785 0
DSLD Entry Date2017-01-25
Product TypeBotanical
FormSoftgel Capsule
DSLD ID69443
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.