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Extra Strength Milk Thistle Extract 450 mg

product on market Softgel Capsule NOW Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Milk thistle extract contains silymarin, which is researched for its potential to support liver function and protect hepatocytes. Current clinical evidence for these effects is considered limited to moderate. The ingredient profile is generally recognized as safe for most users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Extra Strength Milk Thistle Extract 450 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
120
Servings
Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)

Other Ingredients

Bovine Gelatin Glycerin Water Caramel color Sunflower Oil Sunflower Lecithin Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1 softgel daily.

Warnings & Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

Milk Thistle has been used by traditional herbalists for centuries. Clinical and non-clinical studies have indicated that Milk Thistle extract may help maintain healthy liver function through its ability to promote glutathione production, as well as by supporting the body’s normal detoxification processes.

Natural color variation may occur in this product.

NOW Extra Strength Silymarin has three times the milk thistle extract (450 mg per softgel) as in our regular strength product (150 mg per capsule).

Silymarin (360 mg)

Detox & liver support Promotes glutathione production Softgels for improved solubility

Non-GMO

Triangle K (Kosher) Contains gelatin

Triangle K (Kosher) Contains gelatin

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or sesame ingredients.

Crescent H (Halal)

Made and quality tested in the USA with globally sourced ingredients.

Additional Information

Triangle K (Kosher) Contains gelatin

Botanicals/Herbs Family owned since 1968.

Store in a cool, dry place after opening.

GMP Quality Assured Crescent H (Halal)

This bottle is made from 100% PCR (post-consumer recycled) resin.

Metadata

Product Details

UPC / SKU7 33739 04785 4
DSLD Entry Date2024-07-25
Product TypeBotanical
FormSoftgel Capsule
BrandNOW
DSLD ID314318
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.