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5-HTP Powder

product on market Powder Chief Originals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan serves as a precursor to serotonin and is supported by moderate evidence for managing depressive symptoms. Research suggests it may help regulate mood and sleep patterns. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Powder
Open Full PDF View on NIH DSLD →
Details

Label Data

0.2 Gram(s)
Serving Size
100
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Warnings & Precautions

If pregnant or under a doctor's care, consult your physician before using this product.

Do not use if the safety seal is broken.

Keep out of the reach of children.

Manufactured in a facility which may contain nuts (peanuts, tree nuts).

Formulation Notes

Extracted from the seed of the Griffonia simplicifolia plant, Chief Originals 5-HTP Powder delivers pure 5-Hydroxytryptophan (5-HTP) to support a healthy mood and promote sleep.

This powder extract contains no gluten or GMO's. It is also vegan, certified Kosher and lab tested for glyphosate, heavy metals and microbiology.

This powder extract contains no gluten or GMO's. It is also vegan, certified Kosher and lab tested for glyphosate, heavy metals and microbiology.

This powder extract contains no gluten or GMO's. It is also vegan, certified Kosher and lab tested for glyphosate, heavy metals and microbiology.

Supports mood and sleep

Glyphosate tested Non-GMO

Vegan

Additional Information

Glyphosate tested Vegan K Kosher

A percent of all profits to Native American causes

Metadata

Product Details

UPC / SKU0 50742 58711 6
DSLD Entry Date2024-03-22
Product TypeAmino acid/Protein
FormPowder
DSLD ID307943
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.