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Pregnenolone 50

product on market Tablet or Pill Allergy Research Group Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for Pregnenolone 50
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg
Market median: 30.0mg (45 products)

Other Ingredients

Micosolle Microcrystalline Cellulose Vegetable Oil Vegetable Wax Cab-o-sil Magnesium Stearate Vitamin E
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use As a dietary supplement, 1 tablet daily with a meal or as directed by a health care professional.

Warnings & Precautions

Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing.

Consult a physician or licensed qualified healthcare professional before using this product if you currently have or have a family history of hormone sensitive cancers or hormone-sensitive diseases. Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone, and/or DHEA.

Keep out of reach of children.

To report any adverse reactions, call 1-833-914-2097

Formulation Notes

Pregnenolone 50 Micronized, plant-sourced pregnenolone formulated in a lipid matrix to bypass the liver, with a particle size of less than 50 microns. Derived from non-irradiated and non-ethylene-oxide-treated wild yam.

Micronized lipid matrix

Hypoallergenic

Additional Information

Keep in a cool, dry place, tightly capped.

Metadata

Product Details

UPC / SKU7 13947 74810 1
DSLD Entry Date2023-12-14
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID304269
Data Updated2026-04-11
Research

Research Evidence

9
Research Sources
38
Avg Quality
5
Rct
2
Narrative Review
2
Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020 PubMed DOI
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022 PubMed DOI
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010 PubMed DOI
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023 PubMed DOI
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 PubMed DOI
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023 PubMed DOI
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016 PubMed DOI
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008 PubMed
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.