🟡 60/100

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  • Vitamin B6: 500mg is 5.0× the Tolerable Upper Intake Level (100mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Vitamin B6: 500mg is 5.0× the Tolerable Upper Intake Level (100mg)

This product received a low safety score because its 500mg dose of Vitamin B6 is five times higher than the recommended maximum daily limit of 100mg.

Label Data

1 Tablet(s) Serving Size
60 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (29412% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 5.0× (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 500mg UL 100mg

Other Ingredients

Hydroxypropyl Methylcellulose Stearic Acid Magnesium Stearate Dicalcium Phosphate Silica Rice Bran Pharmaceutical Glaze

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) No Allergies Gluten Free

Product Information

📋 Directions for Use

Directions: One tablet daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

Do not exceed one tablet per day without consulting your physician, as some people may have an adverse reaction.

🧪 Formulation Notes

Free from artificial colors and artificial preservatives. Free from all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Vegetarian

Gluten free

In a special base which provides for the gradual release of ingredients over a prolonged period of time. Micro-gel sustained release system

Energy support

Additional Information

Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 0 97467 01665 1
DSLD Entry Date 2023-09-25
Product Type Vitamin
Form Tablet or Pill
Brand NaturesPlus
DSLD ID 298454
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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