🟡 60/100

Review before taking

  • Manganese: 50mg is 4.5× the Tolerable Upper Intake Level (11mg)
  • Limited research evidence available for ingredients
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Manganese: 50mg is 4.5× the Tolerable Upper Intake Level (11mg)

This supplement received a low safety score because the amount of manganese provided is 4.5 times higher than the recommended maximum daily limit.

Label Data

1 Tablet(s) Serving Size
90 Servings
Mineral Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

50 mg (2174% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.5× (UL: 11 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 50mg UL 11mg

Other Ingredients

Microcrystalline Cellulose Cellulose Stearic Acid Dicalcium Phosphate Silica Magnesium Stearate Pharmaceutical Glaze

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (74% of products) Nutrient (37% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: One tablet daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

🧪 Formulation Notes

Manganese promotes protein and fat metabolism, energy production, healthy nerves, immune defenses and blood sugar regulation. It also supports the formation of cartilage and synovial fluid of the joints, promotes normal bone growth and supports healthy reproductive function.

Free from artificial colors and artificial preservatives.

Overall wellness

Vegetarian

Gluten free

Additional Information

Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 0 97467 03450 1
DSLD Entry Date 2023-10-24
Product Type Mineral
Form Tablet or Pill
Brand NaturesPlus
DSLD ID 298444
Data Updated 2026-04-11

Research Evidence

11 Research Sources
47 Avg Quality Score
7 Rct
2 Meta Analysis
1 Regulatory Source
C Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis
Meta Analysis Environmental pollution (Barking, Essex : 1987) 2023
C Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone
Rct Journal of animal science 2010
C Reducing mineral usage in feedlot diets for Nellore cattle: II. Impacts of calcium, phosphorus, copper, manganese, and zinc contents on intake, performance, and liver and bone status
Rct Journal of animal science 2017
C Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson's Disease Patients: Systematic Review and Meta-Analysis
Meta Analysis Cells 2026
C Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group
Rct The Journal of clinical endocrinology and metabolism 2000
C Dietary Reference Intakes: Manganese
Regulatory Source IOM/NAM Dietary Reference Intakes 2000
C Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.
Rct Bone marrow transplantation
C Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
Rct Endocrine, metabolic & immune disorders drug targets
C Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
Rct Military medicine 1999
C Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.
Rct Dermatologic therapy
View all evidence for Manganese →

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