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Milk Thistle

product on market Capsule NutraKey Health Performance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Milk thistle seed extract contains silymarin, which is researched for its potential to support liver health and protect hepatic cells. Current scientific evidence for these effects is generally considered limited to moderate. This ingredient profile maintains a high safety rating for most users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Milk Thistle
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 250.0mg (562 products) 55 studies (A:0, B:19)

Other Ingredients

Gelatin Rice Flour
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended Use: Take 1 serving (1 capsule) with water or your favorite beverage twice daily on an empty stomach. Take first serving 30 minutes prior to breakfast. Take second 30 minutes prior to lunch. For added benefits drink 64 ounces of water daily.

Warnings & Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Do not use if seal is broken.

Formulation Notes

Antioxidants play an essential role in liver detox Milk Thistle Extract has been shown in numerous studies to support healthy liver function and has been used for over 2,000 years as a natural supplement for liver disorders. Silymarin is the main active ingredient in milk thistle and is both an anti-inflammatory and antioxidant.

Promote healthy liver Protect against free-radicals Support toxin removal Healthy regeneration

Help prevent cell damage Antioxidants protect your healthy cells from damaging free radicals. Free radicals are molecules that can cause damage to healthy cells and make them unstable.

High-Performance Liquid Chromatography (HPLC) Verified

Ultra pure ingredients Ultra micronized Max bioavailability Healthy liver function Detoxification & cleansing Boost immune function Natural ingredients

Silymarin is a standardized extract in milk thistle. Silibinin is the most active chemical in silymarin and is hypothesized to function by displacing toxins trying to bind to the liver, as well as by helping the liver to regenerate more quickly.

Additional Information

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Made in the USA

Health essentials

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Metadata

Product Details

UPC / SKU0 45635 77477 3
DSLD Entry Date2023-06-22
Product TypeBotanical
FormCapsule
DSLD ID287418
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.