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Magnesium Breakthrough

product on market Capsule BiOptimizers Safety: 80/100
80/100

This product is generally safe

  • Elemental Magnesium: 500mg is 1.4× the Tolerable Upper Intake Level (350mg)
  • Magnesium Proprietary Blend: 1711mg is 4.9× the Tolerable Upper Intake Level (350mg)
  • 75% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Elemental magnesium and vitamin B6 are supported by moderate evidence for supporting nerve function and metabolic health. Manganese provides essential cofactor support for various enzymatic processes. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Elemental Magnesium: 500mg is 1.4× the Tolerable Upper Intake Level (350mg)

Magnesium Proprietary Blend: 1711mg is 4.9× the Tolerable Upper Intake Level (350mg)

Label

Product Label

Label for Magnesium Breakthrough
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Mineral
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
500 mg (120% DV)
Exceeds UL by 1.4× (UL: 350 mg) 316 studies (A:8, B:159)
Exceeds UL by 4.9× (UL: 350 mg) 316 studies (A:8, B:159)
1 mg (43% DV)
Within RDA (0.4× RDA) 9 studies — no high-quality reviews

Other Ingredients

Cellulose Nu-Mag Nu-Flow Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 capsules with your evening meal.

Warnings & Precautions

Caution: Keep out of reach of children.

As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.

Formulation Notes

Magnesium Breakthrough combines 7 types of magnesium in a humic/fulvic monoatomic blend, to optimize absorption. And to our knowledge, it's the most complete magnesium supplement blend available. May support digestion and promote more restful sleep.

Premium magnesium complex

Additional Information

Store in a cool/dry location away from direct light.

To reorder or contact us, please visit: BiOptimizers.com

Optimized nutrition solutions

Metadata

Product Details

UPC / SKU0 750363 800754
DSLD Entry Date2023-02-21
Product TypeMineral
FormCapsule
BrandBiOptimizers
DSLD ID284047
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.