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5-HTP 5-Hydroxytryptophan 100 mg

product on market Other (e.g. tea bag) Natural Factors Stress-Relax Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

5-HTP is a precursor to serotonin used in research to support mood and sleep, though evidence coverage for this specific formulation is limited. Calcium serves as a fundamental mineral for bone health and neuromuscular function. There is moderate evidence supporting the general efficacy of these ingredients for their respective roles.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 5-Hydroxytryptophan 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
120
Servings
Fat/Fatty Acid
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
70 mg (5% DV)
100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Microcrystalline Cellulose Carbohydrate Gum Glycerin Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested usage: 1 caplet 2-3 times per day with meals or as directed by a health professional. To minimize the risk of gastrointestinal side effects, slowly increase dose over a period of 2 weeks.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication or supplements with serotonergic activity (specifically those with SSRIs, MOAs, or depressant/sedative affect), have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation Notes

Supplementing with 5-HTP provides natural support for emotional well-being, and caplets are time released to minimize gastric discomfort and optimize absorption. Natural Factors amino acids are the highest quality pharmaceutical grade products available.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Product of Canada

Emotional well-being

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Additional Information

isura Non-GMO - Mass spec Documentation - Lab tested

For freshness, store in a cool, dry place.

Recyclable container and label.

Metadata

Product Details

UPC / SKU0 68958 02846 0
DSLD Entry Date2023-01-23
Product TypeFat/Fatty Acid
FormOther (e.g. tea bag)
DSLD ID282149
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.