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Magnesium Orotate 500 mg

product on market Tablet or Pill Advanced Research Safety: 60/100
60/100

Review before taking

  • Magnesium: 2000mg is 5.7× the Tolerable Upper Intake Level (350mg)
  • Magnesium: 1000mg is 2.9× the Tolerable Upper Intake Level (350mg)
  • 100% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Magnesium orotate is used to support cellular energy and muscle function, though research evidence for this specific form is limited. While magnesium is essential for various physiological processes, the safety score indicates potential concerns regarding tolerability or dosage. Consult a professional to ensure this supplement is appropriate for your needs.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Magnesium: 2000mg is 5.7× the Tolerable Upper Intake Level (350mg)

Magnesium: 1000mg is 2.9× the Tolerable Upper Intake Level (350mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of magnesium provided exceeds the recommended daily upper limit for adults.

Label

Product Label

Label for Magnesium Orotate 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
12
Servings
Mineral
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2000 mg (30% DV)
Exceeds UL by 5.7× (UL: 350 mg) 316 studies (A:8, B:159)
1000 mg (15% DV)
Exceeds UL by 2.9× (UL: 350 mg) 316 studies (A:8, B:159)

Other Ingredients

Microcrystalline Cellulose silicified Microcrystalline Cellulose natural Glaze Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: As an addition to the daily diet, take one or two tablets before morning and evening meals, individuals fifty years of age or older take four tablets before morning and evening meals, or as directed by your health care professional.

Warnings & Precautions

If you are pregnant or a nursing mother, consult your health care professional before using this or any dietary supplement.

Children: Consult your health care professional before giving this or any dietary supplement to children. Keep out of reach of children

Formulation Notes

Made in the USA

Additional Information

Keep bottle tightly closed and store in a cool, dry place.

Formulated by Hans A. Nieper, M.D. of Hannover, Germany

Servings Per Container 25, approx. 12

Metadata

Product Details

UPC / SKU6 05164 34081 0
DSLD Entry Date2023-03-22
Product TypeMineral
FormTablet or Pill
BrandAdvanced Research
DSLD ID273588
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.