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Calcium Orotate 500 mg

product on market Capsule Advanced Research Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Calcium and magnesium are essential minerals that support bone density and neuromuscular function. There is strong evidence for their role in skeletal health, although evidence specific to the orotate form is limited. This profile maintains a high safety rating.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Calcium Orotate 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
1500
Servings
Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
1500 mg (12% DV)
338 mg (9% DV)
Within RDA (0.8× RDA) 316 studies (A:8, B:159)

Other Ingredients

Microcrystalline Cellulose natural Glaze modified Cellulose Gum Compritol Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: As an addition to the daily diet, take two to three capsules with evening meals or as directed by your health care professional.

Warnings & Precautions

If you are pregnant or a nursing mother, consult your health care professional before using this or any dietary supplement.

Children: Consult your health care professional before giving this or any dietary supplement to children. Keep out of reach of children

Formulation Notes

Made in the USA

Additional Information

Keep bottle tightly closed and store in a cool, dry place.

Formulated by Hans A. Nieper, M.D. of Hannover, Germany

Metadata

Product Details

UPC / SKU6 05164 34092 6
DSLD Entry Date2023-03-22
Product TypeMineral
FormCapsule
BrandAdvanced Research
DSLD ID273584
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.