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Milk Thistle 280 mg Extract

product on market Capsule Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Milk thistle seed extract is traditionally used to support liver health and protect against certain toxins. Current clinical evidence for these effects is limited and often inconsistent across studies. The ingredient is generally considered safe for most users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Milk Thistle 280 mg Extract
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 250.0mg (562 products) 55 studies (A:0, B:19)

Other Ingredients

Cellulose Gel Gelatin Silicon Dioxide Stearic Acid Water Dibasic Calcium Phosphate Ethylcellulose Hydroxypropyl Methylcellulose Maltodextrin Lactose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

1 DOSE PER DAY

Suggested Use: As an addition to the diet, take one capsule daily with water before mealtimes.

Warnings & Precautions

Keep out of reach of children.

If you are pregnant or nursing, consult a health professional before taking this product.

DO NOT USE IF IMPRINTED SEAL UNDER CAP IS BROKEN OR MISSING.

Contains: Milk.

Formulation Notes

No Artificial Colors - No Artificial Flavors No Preservatives - No Yeast, Starch or Gluten

Contains: Milk.

Additional Information

NEW LOOK!

List No. 14162 L300AA Cat. A082 5J030

TIME RELEASE

Helps Maintain Healthy Liver Function

PURITY Guaranteed QUALITY(R)

Enter Code for Wellness Rewards Points at www.NatureMade.com

Milk Thistle helps maintain healthy liver function through its antioxidant properties. It is frequently used by people concerned with cigarette smoke, alcohol and other environmental toxins. Nature Made Time Release Milk Thistle provides all the benefits you have come to expect from our regular herb products with the added convenience of one capsule a day dosing. Nature Made Time Release Milk Thistle provides a 12-hour release of the herbal benefits you seek at a low cost per day.

Color variation is normal in this product.

Milk Thistle Capsules are made to Nature Made's guaranteed purity and potency standards.

Valid only for U.S. and Puerto Rico residents.

Metadata

Product Details

UPC / SKU3 31604 14162 3
DSLD Entry Date2013-10-25
Product TypeOther Combinations
FormCapsule
DSLD ID26673
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.