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Formula 256

product on market Tablet or Pill DC Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Melatonin is supported by strong evidence for improving sleep onset and duration. Vitamin B6 plays a moderate role in supporting neurotransmitter synthesis. Overall, the evidence coverage for this specific ingredient combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Formula 256
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
45
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

0.5 mg (25% DV)
Within RDA (0.4× RDA) 114 studies (A:3, B:35)
2.5 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)

Other Ingredients

Dextrose Stearic Acid Vegetable Magnesium Stearate Silica Orange crystals Orange flavor
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Adults, allow one tablet to dissolve under tongue 20 minutes before bedtime. Read warning section of label prior to taking product.

Warnings & Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Warning: This product is not to be taken by pregnant or lactating women, individuals with autoimmune conditions or depressive disorders, or children under 16 years of age.

Warning: This product is not to be taken by pregnant or lactating women, individuals with autoimmune conditions or depressive disorders, or children under 16 years of age.

Do not take this product when driving a motor vehicle or operating machinery.

Do not exceed two tablets in any 24 hour period.

Formulation Notes

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight.

Made in USA

Gluten free

Melatonin 2.5 mg (2,500 mcg) Sublingual fruit flavored

Nutritionally supports a healthy sleep pattern

Additional Information

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Quali Pure

Metadata

Product Details

DSLD Entry Date2022-02-23
Product TypeOther Combinations
FormTablet or Pill
BrandDC
DSLD ID266581
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.