🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

Calcium
40 mg (4% DV)
MSM
1000 mg
📊 Market median: 1000.0mg (2 products)
This product: 1000mg

Other Ingredients

Cellulose Contains Less Than 2% of

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet with any meal, three (3) times daily or as directed by a healthcare provider.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

🧪 Formulation Notes

Methylsulfonylmethane (MSM) is an organic source or sulfur which provides support for joints and connective tissues.

No added sugar, preservatives, artificial flavors or colors.

Methylsulfonylmethane 1000 mg

Joint function support

Gluten free

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed Quality Laboratory Tested

Product Details

UPC / SKU 7 40985 22278 2
DSLD Entry Date 2020-08-23
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 233576
Data Updated 2026-04-11

Research Evidence

849 Research Sources
56 Avg Quality Score
450 Meta Analysis
152 Rct
137 Systematic Review
73 Clinical Trial
11 Regulatory Source
7 Other
7 Guideline
3 Openfda Safety
2 Cochrane Review
2 Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021
View all evidence for Electrolytes →

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